HTML
<!-- Region -->
<div class="infoblock">
    <label class='label output' name="regio"></label>
    <img src="../../../icons/help.png" style="width:18px; cursor:pointer;"
      onclick="S10Apply('fieldhelp', 'regio', this, true, true); return false;"/>
    <br />
    <span class='output' name='regio'></span>
    <span class='output' name='regio@text'></span>
</div>

ABAP
method fieldhelp.
  data: fname type string.
  fname = s10actionparameter( ).

  s10infomessage(
     text = s10fieldlabel( fname )
     explanation = s10fieldhelp( fname )
     htmlformat = 'X' ).

  endmethod.

Instead of an icon "help.png" you can also use a UTF-8 character for display:

<label class='label output' name="regio"></label>
<span class='label' style='cursor:pointer;'
  onclick="S10Apply('fieldhelp', 'regio', this, true, true); return false;">
     ⍰
</span>
<br />
<span class='output' name='regio'></span>
<span class='output' name='regio@text'></span>

Another way of displaying the label in this case is to underline it. To achieve a uniform display, it is best to define the appearance in the central CSS file "style/custom.style.css" in your project:

CSS
 /* custom.style.css */

.label.fieldhelp {
    cursor:pointer;
    text-decoration:underline;

HTML
 <label class='label output fieldhelp' name="regio"
     onclick="S10Apply('fieldhelp', 'regio', this, true, true); return false;">
 </label>
           
 <br />
 <span class='output' name='regio'></span>
 <span class='output' name='regio@text'></span>}